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Vince grew up near Minneapolis, and later attended the University of Minnesota, receiving his B.S. in Physics in 1999.   As an undergraduate, he worked on biophysical modeling and spectroscopy in the laboratory of Prof. David D. Thomas.   He then pursued graduate work in computational biophysics at the University of California-San Francisco, working in the laboratory of Prof. Ken Dill on computational studies of protein folding, receiving a Ph.D. in Biophysics in 2007.   Vince then worked as postdoctoral fellow in the laboratory of Prof. Vijay Pande at Stanford University, using distributed computing and kinetic network models to study protein folding.  His independent career began in 2011 at Temple University in Philadelphia, where he is a member of the Institute for Computational Molecular Science.  His work focuses on molecular simulation methods for studying conformational dynamics and peptidomimetic design.