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Postdoctoral position open in the Voelz Lab

posted Sep 12, 2011, 9:24 AM by Vincent Voelz
Our lab is developing new computational methods to design folding and binding properties of proteins and peptide mimetics. Projects include: (1) developing Markov State Model (MSM) approaches for modeling the folding reaction and designing sequences for folding properties (2) simulation-based prediction and design of non-biological (e.g. peptoid) foldamers (3) multiscale fragment-based approaches for predicting binding affinities and specificities of protein-peptide interactions. 

The lab benefits greatly from high-performance computing resources and collaborations available through the Institute for Computational Molecular Science (, and inter-disciplinary collaborations through the new Moulder Center for Drug Discovery in the School of Pharmacy. 

Applicant should have a Ph.D in computational/physical chemistry, biophysics, chemical engineering, or related field, and a strong background in molecular simulation, physical chemistry, statistical mechanics of biomolecular systems, and/or computational biophysics. Relevant research experience may include: conformational sampling using molecular dynamics or Monte Carlo simulation, free energy estimation, methods for estimating protein-ligand affinities, protein structure prediction, forcefield development, multiscale modeling. 

Good programming skills are essential, as the applicant will be responsible for writing new simulation algorithms and extending existing code bases. Other relevant skills include: familiarity with simulation/modeling packages such as AMBER, GROMACS, OpenMM; Python scripting experience; familiarity with UNIX; experience with large-scale scientific computing. Experience with parallel computing and/or GPUs a plus.

Start date: negotiable (early 2012)
Salary: Competitive and commensurate with experience.
One-year appointment, with the option to extend contingent on satisfactory progress.

To apply: Email a cover letter and your full CV (details of all academic degrees obtained, research skills and experience, publications, conference presentations) preferrably as a single PDF, along with 2-3 letters of recommendation, to Prof. Vincent Voelz (

See also our posting at